Human IGF2BP3 Recombinant Protein (N-His) (HT269012)

Name: Human IGF2BP3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HT269012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HT269012
Description	Recombinant Human IGF2BP3 Protein, N-His (HT269012) expressed in E. coli, spanning Asn2-Ile343. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O00425
Protein length	Asn2-Ile343
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Insulin-like growth factor 2 mRNA-binding protein 3, VICKZ3, IGF2BP3, IMP3, KH domain-containing protein overexpressed in cancer, IMP-3, VICKZ family member 3, IGF-II mRNA-binding protein 3, KOC1, hKOC, IGF2 mRNA-binding protein 3
Background	Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is a ~63 kDa protein. RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. 1. Huang, H. et al. (2018) Nature cell biology 20, 285-295. PMID: 29476152
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Recombinant Human IGF2BP3 Protein, N-His

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Datasheet

Human IGF2BP3 Recombinant Protein (N-His).pdf

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Human IGF2BP3 Recombinant Protein (N-His) (HT269012)

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