Human IKZF2 Recombinant Protein (N-His) (HD731012)

Name: Human IKZF2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD731012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD731012
Description	Recombinant Human IKZF2 Protein, N-His (HD731012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9UKS7
Protein length	Asp92-Met227
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HELIOS, IKZF2, Ikaros family zinc finger protein 2, ZNFN1A2, Zinc finger protein Helios
Background	Zinc finger protein Helios is a ~59 kDa protein. Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs). May possibly act via STAT5-mediated signaling. Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter. In Tregs, required for FOXP3 recruitment to the IL2 promoter. Required for outer hair cells maturation and, consequently, for hearing. 1. Mohajeri, A. et al. (2023) Journal of medical genetics 60, 1092-1104. PMID: 37316189
Note	For research use only

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Datasheet

Human IKZF2 Recombinant Protein (N-His).pdf

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Formula

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Human IKZF2 Recombinant Protein (N-His) (HD731012)

Overview

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