Human ITSN1 Recombinant Protein (N-His) (HD585012)

Name: Human ITSN1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD585012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD585012
Description	Recombinant Human ITSN1 Protein, N-His (HD585012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q15811
Protein length	Asp1216-Leu1445
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ITSN, ITSN1, Intersectin-1, SH3 domain-containing protein 1A, SH3D1A, SH3P17
Background	Intersectin-1 is a ~195 kDa protein. Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles. Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. 1. Hussain, NK. et al. (2001) Nature cell biology 3, 927-32. PMID: 11584276 2. Almeida-Souza, L. et al. (2018) Cell 174, 325-337.e14. PMID: 29887380 3. Teckchandani, A. et al. (2012) Molecular biology of the cell 23, 2905-16. PMID: 22648170 4. Jenna, S. et al. (2002) The Journal of biological chemistry 277, 6366-73. PMID: 11744688
Note	For research use only

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Datasheet

Human ITSN1 Recombinant Protein (N-His).pdf

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Human ITSN1 Recombinant Protein (N-His) (HD585012)

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