Human JMJD1C Recombinant Protein (N-His) (HD245012)

Name: Human JMJD1C Recombinant Protein (N-His)
Brand: abinScience
SKU: HD245012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD245012
Description	Recombinant Human JMJD1C Protein, N-His (HD245012) expressed in E. coli, spanning Glu2141-Glu2502. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q15652
Protein length	Glu2141-Glu2502
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	43.62 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:1.14.11.-, JHDM2C, JMJD1C, Jumonji domain-containing protein 1C, KIAA1380, Probable JmjC domain-containing histone demethylation protein 2C, TR-interacting protein 8, TRIP-8, TRIP8, Thyroid receptor-interacting protein 8
Background	Jumonji domain-containing protein 1C is a ~284 kDa protein. Demethylates lysine in proteins, such as STAT3 or MDC1. Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair. Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation. It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do. Nevertheless, JMJD1C may act as a context-specific histone demethylase. 1. Watanabe, S. et al. (2013) Nature structural & molecular biology 20, 1425-33. PMID: 24240613 2. Brauchle, M. et al. (2013) PloS one 8, e60549. PMID: 23593242 3. Viscarra, JA. et al. (2020) Nature communications 11, 796. PMID: 32034158
Note	For research use only

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Datasheet

Human JMJD1C Recombinant Protein (N-His).pdf

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Human JMJD1C Recombinant Protein (N-His) (HD245012)

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