Human KCNAB1 Recombinant Protein (N-His) (HC265012)

Name: Human KCNAB1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC265012
Price: 211 USD
Availability: InStock

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Catalog No.	HC265012
Description	Recombinant Human KCNAB1 Protein, N-His (HC265012) expressed in E. coli, spanning Met89-Ser419. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q14722
Protein length	Met89-Ser419
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	39.23 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:1.1.1.-, K(+) channel subunit beta-1, KCNA1B, KCNAB1, Kv-beta-1, Voltage-gated potassium channel subunit beta-1
Background	Voltage-gated potassium channel subunit beta-1 is a ~46 kDa protein. Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones. The binding of NADPH is required for efficient down-regulation of potassium channel activity. 1. Imbrici, P. et al. (2006) The European journal of neuroscience 24, 3073-83. PMID: 17156368 2. Tipparaju, SM. et al. (2007) Biochemical and biophysical research communications 359, 269-76. PMID: 17540341 3. Peters, CJ. et al. (2009) Channels (Austin, Tex.) 3, 314-22. PMID: 19713757 4. England, SK. et al. (1995) The Journal of biological chemistry 270, 28531-4. PMID: 7499366 5. England, SK. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 6309-13. PMID: 7603988 6. Accili, EA. et al. (1998) The Journal of physiology 512 ( Pt 2), 325-36. PMID: 9763623 7. Maylie, B. et al. (2002) The Journal of neuroscience : the official journal of the Society for Neuroscience 22, 4786-93. PMID: 12077175 8. Williams, CP. et al. (2002) The Journal of pharmacology and experimental therapeutics 302, 545-50. PMID: 12130714 9. Bhalla, T. et al. (2004) Nature structural & molecular biology 11, 950-6. PMID: 15361858 10. McCormack, K. et al. (1995) FEBS letters 370, 32-6. PMID: 7649300
Note	For research use only

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Human KCNAB1 Recombinant Protein (N-His).pdf

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Human KCNAB1 Recombinant Protein (N-His) (HC265012)

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