Human KCNJ11/Kir6.2 Recombinant Protein (N-His) (HC443012)

Name: Human KCNJ11/Kir6.2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC443012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC443012
Description	Recombinant Human KCNJ11/Kir6.2 Protein, N-His (HC443012) expressed in E. coli, spanning Gln173-Ser390. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q14654
Protein length	Gln173-Ser390
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	26.42 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ATP-sensitive inward rectifier potassium channel 11, IKATP, Inward rectifier K(+) channel Kir6.2, KCNJ11, Potassium channel, inwardly rectifying subfamily J member 11
Background	ATP-sensitive inward rectifier potassium channel 11 is a ~43 kDa protein. Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. 1. Lee, KPK. et al. (2017) eLife 6. PMID: 29286281 2. Zhao, C. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34815345
Note	For research use only

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Datasheet

Human KCNJ11/Kir6.2 Recombinant Protein (N-His).pdf

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Human KCNJ11/Kir6.2 Recombinant Protein (N-His) (HC443012)

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