Human KCNJ2/Kir2.1 Recombinant Protein (N-His) (HX945012)

Name: Human KCNJ2/Kir2.1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HX945012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HX945012
Description	Recombinant Human KCNJ2/Kir2.1 Protein, N-His (HX945012) expressed in E. coli, spanning Lys185-Glu349. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P63252
Protein length	Lys185-Glu349
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	21.48 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Cardiac inward rectifier potassium channel, IRK-1, IRK1, Inward rectifier K(+) channel Kir2.1, Inward rectifier potassium channel 2, KCNJ2, Potassium channel, inwardly rectifying subfamily J member 2, hIRK1
Background	Inward rectifier potassium channel 2 is a ~48 kDa protein. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. 1. Fernandes, CAH. et al. (2022) Science advances 8, eabq8489. PMID: 36149965 2. Wood, LS. et al. (1995) Gene 163, 313-7. PMID: 7590287 3. Tare, M. et al. (1998) The Journal of physiology 506 ( Pt 2), 303-18. PMID: 9490857 4. Raab-Graham, KF. et al. (1994) Neuroreport 5, 2501-5. PMID: 7696590
Note	For research use only

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Datasheet

Human KCNJ2/Kir2.1 Recombinant Protein (N-His).pdf

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Human KCNJ2/Kir2.1 Recombinant Protein (N-His) (HX945012)

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