Human KCNK10 Recombinant Protein (N-His) (HD421012)

Name: Human KCNK10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD421012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD421012
Description	Recombinant Human KCNK10 Protein, N-His (HD421012) expressed in E. coli, spanning Ser393-Asp497. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P57789
Protein length	Ser393-Asp497
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	14.37 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	KCNK10, Outward rectifying potassium channel protein TREK-2, Potassium channel subfamily K member 10, TREK-2 K(+) channel subunit, TREK2
Background	Potassium channel subfamily K member 10 is a ~59 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. 1. Lesage, F. et al. (2000) The Journal of biological chemistry 275, 28398-405. PMID: 10880510 2. Dong, YY. et al. (2015) Science (New York, N.Y.) 347, 1256-9. PMID: 25766236 3. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430 4. Sorum, B. et al. (2024) Nature communications 15, 3142. PMID: 38605031 5. Royal, P. et al. (2019) Neuron 101, 232-245.e6. PMID: 30573346
Note	For research use only

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Datasheet

Human KCNK10 Recombinant Protein (N-His).pdf

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Human KCNK10 Recombinant Protein (N-His) (HD421012)

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