Human KCNMA1 Recombinant Protein (N-His) (HD176012)

Name: Human KCNMA1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD176012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD176012
Description	Recombinant Human KCNMA1 Protein, N-His (HD176012) expressed in E. coli, spanning Lys408-Arg716. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q12791
Protein length	Lys408-Arg716
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	37.82 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BK channel, BKCA alpha, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, KCNMA, KCNMA1, KCa1.1, Maxi K channel, MaxiK, SLO, Slo homolog, Slo-alpha, Slo1, Slowpoke homolog, hSlo
Background	Calcium-activated potassium channel subunit alpha-1 is a ~137 kDa protein. Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. 1. Tang, XD. et al. (2003) Nature 425, 531-5. PMID: 14523450 2. Li, X. et al. (2018) European journal of human genetics : EJHG 26, 220-229. PMID: 29330545 3. Liang, L. et al. (2019) Human molecular genetics 28, 2937-2951. PMID: 31152168 4. Niu, L. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 25128-25137. PMID: 32958651
Note	For research use only

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Datasheet

Human KCNMA1 Recombinant Protein (N-His).pdf

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Human KCNMA1 Recombinant Protein (N-His) (HD176012)

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