Human KDM5A Recombinant Protein (N-His) (HC920012)

Name: Human KDM5A Recombinant Protein (N-His)
Brand: abinScience
SKU: HC920012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC920012
Description	Recombinant Human KDM5A Protein, N-His (HC920012) expressed in E. coli, spanning Thr362-Arg607. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P29375
Protein length	Thr362-Arg607
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	30.8 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:1.14.11.67, Histone demethylase JARID1A, JARID1A, Jumonji/ARID domain-containing protein 1A, KDM5A, Lysine-specific demethylase 5A, RBBP-2, RBBP2, RBP2, Retinoblastoma-binding protein 2, [histone H3]-trimethyl-L-lysine(4) demethylase 5A
Background	Lysine-specific demethylase 5A is a ~192 kDa protein. Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. 1. Tu, S. et al. (2008) Nature structural & molecular biology 15, 419-21. PMID: 18270511 2. Wang, GG. et al. (2009) Nature 459, 847-51. PMID: 19430464 3. Horton, JR. et al. (2016) Cell chemical biology 23, 769-781. PMID: 27427228
Note	For research use only

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Datasheet

Human KDM5A Recombinant Protein (N-His).pdf

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Human KDM5A Recombinant Protein (N-His) (HC920012)

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