Human KDM6A Recombinant Protein (N-His) (HC897012)

Name: Human KDM6A Recombinant Protein (N-His)
Brand: abinScience
SKU: HC897012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC897012
Description	Recombinant Human KDM6A Protein, N-His (HC897012) expressed in E. coli, spanning Ala925-Pro14. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O15550
Protein length	Ala925-Pro14
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	100.71 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:1.14.11.68, Histone demethylase UTX, KDM6A, Lysine-specific demethylase 6A, UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, [histone H3]-trimethyl-L-lysine(27) demethylase 6A
Background	Lysine-specific demethylase 6A is a ~154 kDa protein. Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. 1. Agger, K. et al. (2007) Nature 449, 731-4. PMID: 17713478 2. Lee, MG. et al. (2007) Science (New York, N.Y.) 318, 447-50. PMID: 17761849 3. Lan, F. et al. (2007) Nature 449, 689-94. PMID: 17851529
Note	For research use only

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Human KDM6A Recombinant Protein (N-His).pdf

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Human KDM6A Recombinant Protein (N-His) (HC897012)

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