Human LTN1 Recombinant Protein (N-His) (HC968012)

Name: Human LTN1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC968012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC968012
Description	Recombinant Human LTN1 Protein, N-His (HC968012) expressed in E. coli, spanning Glu1587-Phe1766. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O94822
Protein length	Glu1587-Phe1766
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	22.96 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C21orf10, C21orf98, E3 ubiquitin-protein ligase listerin, EC:2.3.2.27, KIAA0714, LTN1, RING finger protein 160, RING-type E3 ubiquitin transferase listerin, RNF160, ZNF294, Zinc finger protein 294
Background	E3 ubiquitin-protein ligase listerin is a ~200 kDa protein. E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product. 1. Shao, S. et al. (2013) Molecular cell 50, 637-48. PMID: 23685075 2. Shao, S. et al. (2014) Molecular cell 55, 880-890. PMID: 25132172 3. Shao, S. et al. (2015) Molecular cell 57, 433-44. PMID: 25578875 4. Matsuo, Y. et al. (2017) Nature communications 8, 159. PMID: 28757607
Note	For research use only

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Human LTN1 Recombinant Protein (N-His).pdf

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Human LTN1 Recombinant Protein (N-His) (HC968012)

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