Human MACF1 Recombinant Protein (N-His) (HD829012)

Name: Human MACF1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD829012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD829012
Description	Recombinant Human MACF1 Protein, N-His (HD829012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9UPN3
Protein length	Arg7114-Lys7387
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	620 kDa actin-binding protein, ABP620, ACF7, Actin cross-linking family protein 7, KIAA0465, KIAA0754, KIAA1251, MACF1, Macrophin-1, Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5, Trabeculin-alpha
Background	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 is a ~838 kDa protein. F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. 1. Kakinuma, T. et al. (2004) Experimental cell research 298, 388-98. PMID: 15265687 2. Zaoui, K. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 18517-22. PMID: 20937854 3. Ning, W. et al. (2016) Developmental cell 39, 61-74. PMID: 27693509
Note	For research use only

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Datasheet

Human MACF1 Recombinant Protein (N-His).pdf

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Human MACF1 Recombinant Protein (N-His) (HD829012)

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