Human MBTPS1 Recombinant Protein (N-His) (HD222012)

Name: Human MBTPS1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD222012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD222012
Description	Recombinant Human MBTPS1 Protein, N-His (HD222012) expressed in E. coli, spanning Arg191-Pro615. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q14703
Protein length	Arg191-Pro615
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	48.59 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.4.21.112, Endopeptidase S1P, KIAA0091, MBTPS1, Membrane-bound transcription factor site-1 protease, S1P, SKI-1, SKI1, Subtilisin/kexin-isozyme 1
Background	Membrane-bound transcription factor site-1 protease is a ~117 kDa protein. Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates include SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6, ATF6B and FAM20C. Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Also mediates the first step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. 1. Touré, BB. et al. (2000) The Journal of biological chemistry 275, 2349-58. PMID: 10644685 2. Okada, T. et al. (2003) The Journal of biological chemistry 278, 31024-32. PMID: 12782636 3. Marschner, K. et al. (2011) Science (New York, N.Y.) 333, 87-90. PMID: 21719679 4. Chen, X. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34349020 7. Murakami, T. et al. (2006) Journal of neurochemistry 96, 1090-100. PMID: 16417584
Note	For research use only

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Human MBTPS1 Recombinant Protein (N-His).pdf

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Human MBTPS1 Recombinant Protein (N-His) (HD222012)

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