Human MCOLN3 Recombinant Protein (N-His) (HA053012)

Name: Human MCOLN3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA053012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HA053012
Description	Recombinant Human MCOLN3 Protein, N-His (HA053012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q8TDD5
Protein length	Asn84-His283
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MCOLN3, Mucolipin-3, TRPML3, Transient receptor potential channel mucolipin 3
Background	Mucolipin-3 is a ~64 kDa protein. Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. 1. Kim, HJ. et al. (2008) The EMBO journal 27, 1197-205. PMID: 18369318 2. Martina, JA. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1143-56. PMID: 19497048 3. Kim, HJ. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1157-67. PMID: 19522758 4. Curcio-Morelli, C. et al. (2010) Journal of cellular physiology 222, 328-35. PMID: 19885840 5. Zhou, X. et al. (2017) Nature structural & molecular biology 24, 1146-1154. PMID: 29106414 6. Lelouvier, B. et al. (2011) The Journal of biological chemistry 286, 9826-32. PMID: 21245134 7. Guo, Z. et al. (2013) PloS one 8, e58174. PMID: 23469151
Note	For research use only

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Datasheet

Human MCOLN3 Recombinant Protein (N-His).pdf

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Human MCOLN3 Recombinant Protein (N-His) (HA053012)

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