Human MICAL2 Recombinant Protein (N-His) (HD957012)

Name: Human MICAL2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD957012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD957012
Description	Recombinant Human MICAL2 Protein, N-His (HD957012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O94851
Protein length	Met1-His486
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:1.14.13.225, KIAA0750, MICAL C-terminal-like protein, MICAL-2, MICAL2, MICAL2PV1, MICAL2PV2, MICALCL, Mical-cL, Molecule interacting with CasL protein 2, [F-actin]-monooxygenase MICAL2
Background	[F-actin]-monooxygenase MICAL2 is a ~219 kDa protein. Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. 1. Lundquist, MR. et al. (2014) Cell 156, 563-76. PMID: 24440334 2. Wu, H. et al. (2018) Scientific reports 8, 937. PMID: 29343822 3. Galloni, C. et al. (2021) The Journal of cell biology 220. PMID: 34106209
Note	For research use only

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Human MICAL2 Recombinant Protein (N-His).pdf

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Human MICAL2 Recombinant Protein (N-His) (HD957012)

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