Human/Mouse/Rat GABRA1 Recombinant Protein (N-His) (HB280012)

Name: Human/Mouse/Rat GABRA1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HB280012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HB280012
Description	Recombinant Human BABRA1 Protein, N-His (HB280012) expressed in E. coli, spanning Arg64-Lys249. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P14867, P62812, P62813
Protein length	Arg64-Lys249
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	23.77 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GABA(A) receptor subunit alpha-1, GABAAR subunit alpha-1, GABRA1, Gamma-aminobutyric acid receptor subunit alpha-1
Background	Gamma-aminobutyric acid receptor subunit alpha-1 is a ~51 kDa protein. Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Alpha-1/GABRA1-containing GABAARs are largely synaptic. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. 1. Fuchs, C. et al. (2013) The European journal of neuroscience 38, 3146-58. PMID: 23909897 2. Brown, LE. et al. (2014) Journal of visualized experiments : JoVE, e52115. PMID: 25489750 3. Zhu, S. et al. (2018) Nature 559, 67-72. PMID: 29950725 4. Laverty, D. et al. (2019) Nature 565, 516-520. PMID: 30602789
Note	For research use only

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Datasheet

Human/Mouse/Rat GABRA1 Recombinant Protein (N-His).pdf

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Human/Mouse/Rat GABRA1 Recombinant Protein (N-His) (HB280012)

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