Human MOV10 Recombinant Protein (N-His) (HC181012)

Name: Human MOV10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC181012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC181012
Description	Recombinant Human MOV10 Protein, N-His (HC181012) expressed in E. coli, spanning Glu498-Arg733. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9HCE1
Protein length	Glu498-Arg733
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	28.50 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Armitage homolog, EC:3.6.4.13, Helicase MOV-10, KIAA1631, MOV10, Moloney leukemia virus 10 protein
Background	Helicase MOV-10 is a ~113 kDa protein. 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. 1. Goodier, JL. et al. (2012) PLoS genetics 8, e1002941. PMID: 23093941 2. Cuevas, RA. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3877-86. PMID: 27016603 3. Balinsky, CA. et al. (2017) Journal of virology 91. PMID: 27974568 4. Yang, X. et al. (2022) PLoS pathogens 18, e1010301. PMID: 35157734 5. Wang, X. et al. (2010) The Journal of biological chemistry 285, 14346-55. PMID: 20215113 6. Chen, C. et al. (2017) Retrovirology 14, 56. PMID: 29258557 7. Liu, T. et al. (2019) The Journal of biological chemistry 294, 19804-19813. PMID: 31722967 8. Gregersen, LH. et al. (2014) Molecular cell 54, 573-85. PMID: 24726324 10. Chendrimada, TP. et al. (2007) Nature 447, 823-8. PMID: 17507929
Note	For research use only

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Human MOV10 Recombinant Protein (N-His).pdf

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Human MOV10 Recombinant Protein (N-His) (HC181012)

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