Human MYSM1 Recombinant Protein (N-His) (HD302012)

Name: Human MYSM1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD302012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD302012
Description	Recombinant Human MYSM1 Protein, N-His (HD302012) expressed in E. coli, spanning Asp557-Met828. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q5VVJ2
Protein length	Asp557-Met828
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	33.35 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2A-DUB, Deubiquitinase MYSM1, EC:3.4.19.-, KIAA1915, MYSM1, Myb-like, SWIRM and MPN domain-containing protein 1
Background	Deubiquitinase MYSM1 is a ~95 kDa protein. Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. 1. Nandakumar, V. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, E3927-36. PMID: 24062447 2. Le Guen, T. et al. (2015) The Journal of allergy and clinical immunology 136, 1619-1626.e5. PMID: 26220525 3. Bahrami, E. et al. (2017) The Journal of allergy and clinical immunology 140, 1112-1119. PMID: 28115216 4. Tian, M. et al. (2020) Cell reports 33, 108297. PMID: 33086059 5. Zhu, P. et al. (2007) Molecular cell 27, 609-21. PMID: 17707232
Note	For research use only

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Datasheet

Human MYSM1 Recombinant Protein (N-His).pdf

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Human MYSM1 Recombinant Protein (N-His) (HD302012)

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