Human NBR1 Recombinant Protein (N-His) (HC166012)

Name: Human NBR1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC166012
Price: 211 USD
Availability: InStock

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Catalog No.	HC166012
Description	Recombinant Human NBR1 Protein, N-His (HC166012) expressed in E. coli, spanning Ser372-Asp479. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q14596
Protein length	Ser372-Asp479
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	14.36 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	1A13B, Cell migration-inducing gene 19 protein, KIAA0049, M17S2, Membrane component chromosome 17 surface marker 2, NBR1, Neighbor of BRCA1 gene 1 protein, Next to BRCA1 gene 1 protein, Protein 1A1-3B
Background	Next to BRCA1 gene 1 protein is a ~107 kDa protein. Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. 1. Walinda, E. et al. (2014) The Journal of biological chemistry 289, 13890-902. PMID: 24692539 2. Zeng, Y. et al. (2021) PLoS pathogens 17, e1009300. PMID: 33577621 3. Nicot, AS. et al. (2014) Autophagy 10, 1036-53. PMID: 24879152 4. Turco, E. et al. (2021) Nature communications 12, 5212. PMID: 34471133 5. Song, H. et al. (2024) International journal of biological sciences 20, 701-717. PMID: 38169523 6. Cai, Y. et al. (2022) Biochemical and biophysical research communications 623, 140-147. PMID: 35914352
Note	For research use only

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Human NBR1 Recombinant Protein (N-His).pdf

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Human NBR1 Recombinant Protein (N-His) (HC166012)

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