Human NISCH Recombinant Protein (N-His) (HV506022)

Name: Human NISCH Recombinant Protein (N-His)
Brand: abinScience
SKU: HV506022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HV506022
Description	Recombinant Human NISCH Protein, N-His (HV506022) expressed in E. coli, spanning Asp1231-Glu1501. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9Y2I1
Protein length	Asp1231-Glu1501
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	32.99 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	I-1, I-1 receptor candidate protein, I1R, I1R candidate protein, IR1, IRAS, Imidazoline receptor 1, Imidazoline receptor antisera-selected protein, Imidazoline-1 receptor, Imidazoline-1 receptor candidate protein, KIAA0975, NISCH, Nischarin, hIRAS
Background	Nischarin is a ~166 kDa protein. Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways.
Note	For research use only

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Datasheet

Human NISCH Recombinant Protein (N-His).pdf

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Human NISCH Recombinant Protein (N-His) (HV506022)

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