Human OCRL Recombinant Protein (N-His) (HE008012)

Name: Human OCRL Recombinant Protein (N-His)
Brand: abinScience
SKU: HE008012
Price: 211 USD
Availability: InStock

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Catalog No.	HE008012
Description	Recombinant Human OCRL Protein, N-His (HE008012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q01968
Protein length	Lys536-Asp901
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.1.3.36, EC:3.1.3.56, EC:3.1.3.86, Inositol polyphosphate 5-phosphatase OCRL, Inositol polyphosphate 5-phosphatase OCRL-1, Lowe oculocerebrorenal syndrome protein, OCRL, OCRL-1, OCRL1, Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
Background	Inositol polyphosphate 5-phosphatase OCRL is a ~104 kDa protein. Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818 2. Schmid, AC. et al. (2004) FEBS letters 576, 9-13. PMID: 15474001 3. Zhang, X. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 4853-6. PMID: 7761412 4. Zhang, X. et al. (1998) The Journal of biological chemistry 273, 1574-82. PMID: 9430698 5. Nakatsu, F. et al. (2015) The Journal of cell biology 209, 85-95. PMID: 25869668 6. Vicinanza, M. et al. (2011) The EMBO journal 30, 4970-85. PMID: 21971085 7. Coon, BG. et al. (2012) Human molecular genetics 21, 1835-47. PMID: 22228094 8. Luo, N. et al. (2012) Human molecular genetics 21, 3333-44. PMID: 22543976 9. Bohdanowicz, M. et al. (2012) Molecular biology of the cell 23, 176-87. PMID: 22072788
Note	For research use only

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Human OCRL Recombinant Protein (N-His).pdf

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Human OCRL Recombinant Protein (N-His) (HE008012)

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