Human PAQR3 Recombinant Protein (N-His-KSI) (HD352012)

Name: Human PAQR3 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HD352012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD352012
Description	Recombinant Human PAQR3 Protein, N-His-KSI (HD352012) expressed in E. coli, spanning His2-Trp74. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q6TCH7
Protein length	His2-Trp74
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	24.37 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	PAQR3, Progestin and adipoQ receptor family member 3, Progestin and adipoQ receptor family member III, RKTG, Raf kinase trapping to Golgi
Background	Progestin and adipoQ receptor family member 3 is a ~36 kDa protein. Golgi-scaffold protein which modulates its interactors acitivies by anchoring them to the Golgi apparatus. Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus. Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis. Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation. 1. Luo, X. et al. (2008) The Biochemical journal 414, 399-406. PMID: 18547165 2. Xu, D. et al. (2015) Nature communications 6, 8100. PMID: 26311497
Note	For research use only

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Datasheet

Human PAQR3 Recombinant Protein (N-His-KSI).pdf

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Human PAQR3 Recombinant Protein (N-His-KSI) (HD352012)

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