Human PDE12 Recombinant Protein (N-His) (HD532012)

Name: Human PDE12 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD532012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD532012
Description	Recombinant Human PDE12 Protein, N-His (HD532012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q6L8Q7
Protein length	Thr276-Lys609
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2',5'-phosphodiesterase 12, 2'-PDE, 2-PDE, EC:3.1.13.4, EC:3.1.4.-, Mitochondrial deadenylase, PDE12
Background	2',5'-phosphodiesterase 12 is a ~67 kDa protein. Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. 1. Wood, ER. et al. (2015) The Journal of biological chemistry 290, 19681-96. PMID: 26055709 2. Rorbach, J. et al. (2011) Nucleic acids research 39, 7750-63. PMID: 21666256 3. Estrella, MA. et al. (2018) Scientific reports 8, 16294. PMID: 30389976
Note	For research use only

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Datasheet

Human PDE12 Recombinant Protein (N-His).pdf

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Human PDE12 Recombinant Protein (N-His) (HD532012)

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