Human CXCL4/PF4 Recombinant Protein (C-Fc) (HY443011)

Name: Human CXCL4/PF4 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HY443011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HY443011
Description	Recombinant Human PF4/CXCL4 Protein, C-Fc (HY443011) expressed in Mammalian Cells, spanning Glu32-Ser101. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P02776
Protein length	Glu32-Ser101
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	36.11 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C-X-C motif chemokine 4, CXCL4, Endothelial cell growth inhibitor, Iroplact, Oncostatin-A, PF-4, PF4, Platelet factor 4, Platelet factor 4, short form, SCYB4
Background	Platelet factor 4 is a ~10 kDa protein. Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. 1. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254 2. Lecomte-Raclet, L. et al. (1998) Blood 91, 2772-80. PMID: 9531587 3. Mueller, A. et al. (2008) Journal of leukocyte biology 83, 875-82. PMID: 18174362 4. Van Raemdonck, K. et al. (2014) Angiogenesis 17, 631-40. PMID: 24469069 5. Yang, C. et al. (2022) Nature communications 13, 3426. PMID: 35701499 6. Affandi, AJ. et al. (2022) Cell reports 38, 110189. PMID: 34986347 7. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524
Note	For research use only

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Datasheet

Human CXCL4/PF4 Recombinant Protein (C-Fc).pdf

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Human CXCL4/PF4 Recombinant Protein (C-Fc) (HY443011)

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