Human PRKACB Recombinant Protein (N-His) (HD981012)

Name: Human PRKACB Recombinant Protein (N-His)
Brand: abinScience
SKU: HD981012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD981012
Description	Recombinant Human PRKACB Protein, N-His (HD981012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P22694
Protein length	Met1-Phe351
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.11.11, PKA C-beta, PRKACB, cAMP-dependent protein kinase catalytic subunit beta
Background	cAMP-dependent protein kinase catalytic subunit beta is a ~40 kDa protein. Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR. 1. Wu, KJ. et al. (2002) Oncogene 21, 7872-82. PMID: 12420224 2. Lignitto, L. et al. (2011) Nature cell biology 13, 412-22. PMID: 21423175 3. Jewell, JL. et al. (2019) eLife 8. PMID: 31112131 4. Aksaas, AK. et al. (2011) Journal of molecular signaling 6, 10. PMID: 21880142
Note	For research use only

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Datasheet

Human PRKACB Recombinant Protein (N-His).pdf

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Human PRKACB Recombinant Protein (N-His) (HD981012)

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