Human RAB10 Recombinant Protein (N-His) (HX991012)

Name: Human RAB10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HX991012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HX991012
Description	Recombinant Human RAB10 Protein, N-His (HX991012) expressed in E. coli, spanning Met1-Thr174. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P61026
Protein length	Met1-Thr174
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	22.04 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.6.5.2, RAB10, Ras-related protein Rab-10
Background	Ras-related protein Rab-10 is a ~22 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB10 is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, RAB10 regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. 1. Hutagalung, AH. et al. (2011) Physiological reviews 91, 119-49. PMID: 21248164 2. Babbey, CM. et al. (2006) Molecular biology of the cell 17, 3156-75. PMID: 16641372 3. English, AR. et al. (2013) Nature cell biology 15, 169-78. PMID: 23263280 4. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148 5. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433 6. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220
Note	For research use only

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Datasheet

Human RAB10 Recombinant Protein (N-His).pdf

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Human RAB10 Recombinant Protein (N-His) (HX991012)

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