Human RAB35 Recombinant Protein (N-His) (HC165012)

Name: Human RAB35 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC165012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC165012
Description	Recombinant Human RAB35 Protein, N-His (HC165012) expressed in E. coli, spanning Met1-Lys178. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q15286
Protein length	Met1-Lys178
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	22.42 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.6.5.2, GTP-binding protein RAY, RAB1C, RAB35, RAY, Ras-related protein Rab-1C, Ras-related protein Rab-35
Background	Ras-related protein Rab-35 is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. 1. Lin, L. et al. (2019) Structure (London, England : 1993) 27, 729-740.e3. PMID: 30905672 2. Rahajeng, J. et al. (2012) Traffic (Copenhagen, Denmark) 13, 82-93. PMID: 21951725 3. Kouranti, I. et al. (2006) Current biology : CB 16, 1719-25. PMID: 16950109
Note	For research use only

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Human RAB35 Recombinant Protein (N-His).pdf

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Human RAB35 Recombinant Protein (N-His) (HC165012)

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