Human RNF144A Recombinant Protein (N-His) (HD794012)

Name: Human RNF144A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD794012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD794012
Description	Recombinant Human RNF144A Protein, N-His (HD794012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P50876
Protein length	Pro16-Leu236
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	E3 ubiquitin-protein ligase RNF144A, EC:2.3.2.31, KIAA0161, RING finger protein 144A, RNF144, RNF144A, UBCE7IP4, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4
Background	E3 ubiquitin-protein ligase RNF144A is a ~32 kDa protein. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol. 1. Ho, SR. et al. (2015) The Journal of biological chemistry 290, 23026-38. PMID: 26216882 2. Ho, SR. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E2646-55. PMID: 24979766 3. Yang, B. et al. (2023) EMBO reports 24, e57528. PMID: 37955227 4. Ho, SR. et al. (2018) The Journal of biological chemistry 293, 16307-16323. PMID: 30171075 5. Han, SH. et al. (2020) Journal of cell science 133. PMID: 33067254
Note	For research use only

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Datasheet

Human RNF144A Recombinant Protein (N-His).pdf

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Human RNF144A Recombinant Protein (N-His) (HD794012)

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