Human SACM1L Recombinant Protein (N-His) (HC816012)

Name: Human SACM1L Recombinant Protein (N-His)
Brand: abinScience
SKU: HC816012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC816012
Description	Recombinant Human SACM1L Protein, N-His (HC816012) expressed in E. coli, spanning Gly192-Thr466. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9NTJ5
Protein length	Gly192-Thr466
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	33.67 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:3.1.3.64, KIAA0851, Phosphatidylinositol-3-phosphatase SAC1, Phosphatidylinositol-4-phosphate phosphatase, SAC1, SACM1L, Suppressor of actin mutations 1-like protein
Background	Phosphatidylinositol-3-phosphatase SAC1 is a ~66 kDa protein. Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3. 1. Mesmin, B. et al. (2013) Cell 155, 830-43. PMID: 24209621 2. Dickson, EJ. et al. (2016) The Journal of cell biology 213, 33-48. PMID: 27044890 3. Zewe, JP. et al. (2018) eLife 7. PMID: 29461204 4. Venditti, R. et al. (2019) The Journal of cell biology 218, 783-797. PMID: 30659099
Note	For research use only

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Datasheet

Human SACM1L Recombinant Protein (N-His).pdf

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Human SACM1L Recombinant Protein (N-His) (HC816012)

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