Human SCN1B Recombinant Protein (N-His) (HD851012)

Name: Human SCN1B Recombinant Protein (N-His)
Brand: abinScience
SKU: HD851012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD851012
Description	Recombinant Human SCN1B Protein, N-His (HD851012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q07699
Protein length	Gly19-Lys149
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	SCN1B, Sodium channel regulatory subunit beta-1
Background	Sodium channel regulatory subunit beta-1 is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. 1. Qin, N. et al. (2003) European journal of biochemistry 270, 4762-70. PMID: 14622265 2. Spampanato, J. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 10022-34. PMID: 15525788 3. Watanabe, H. et al. (2008) The Journal of clinical investigation 118, 2260-8. PMID: 18464934 4. Patino, GA. et al. (2009) The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 10764-78. PMID: 19710327 5. Baroni, D. et al. (2018) Human mutation 39, 1402-1415. PMID: 29992740 6. Fan, X. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2220578120. PMID: 36696443 7. Makita, N. et al. (1994) The Journal of biological chemistry 269, 7571-8. PMID: 8125980 8. McClatchey, AI. et al. (1993) Human molecular genetics 2, 745-9. PMID: 8394762 9. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606
Note	For research use only

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Datasheet

Human SCN1B Recombinant Protein (N-His).pdf

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Human SCN1B Recombinant Protein (N-His) (HD851012)

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