Human SEPHS1 Recombinant Protein (N-His) (HW700012)

Name: Human SEPHS1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW700012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HW700012
Description	Recombinant Human SEPHS1 Protein, N-His (HW700012) expressed in E. coli, spanning Ser2-Ser392. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P49903
Protein length	Ser2-Ser392
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	45.22 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.9.3, SELD, SEPHS1, SPS, SPS1, Selenide, water dikinase 1, Selenium donor protein 1, Selenophosphate synthase 1
Background	Zincore component SEPHS1 is a ~42 kDa protein. Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. 1. Bianchi, D. et al. (2025) Science (New York, N.Y.) 389, eadv2861. PMID: 40608935 2. Lee, MO. et al. (2019) Biochemical and biophysical research communications 520, 406-412. PMID: 31607477 3. Low, SC. et al. (1995) The Journal of biological chemistry 270, 21659-64. PMID: 7665581 4. Tamura, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 16162-7. PMID: 15534230
Note	For research use only

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Datasheet

Human SEPHS1 Recombinant Protein (N-His).pdf

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Human SEPHS1 Recombinant Protein (N-His) (HW700012)

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