Human SERINC3 Recombinant Protein (N-His-KSI) (HD200012)

Name: Human SERINC3 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HD200012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD200012
Description	Recombinant Human SERINC3 Protein, N-His-KSI (HD200012) expressed in E. coli, spanning Gly2-Lys96. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q13530
Protein length	Gly2-Lys96
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	26.11 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DIFF33, SERINC3, Serine incorporator 3, TDE1, Tumor differentially expressed protein 1
Background	Serine incorporator 3 is a ~52 kDa protein. Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity. 1. Usami, Y. et al. (2015) Nature 526, 218-23. PMID: 26416733 2. Rosa, A. et al. (2015) Nature 526, 212-7. PMID: 26416734 3. Leonhardt, SA. et al. (2023) Nature communications 14, 4368. PMID: 37474505
Note	For research use only

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Datasheet

Human SERINC3 Recombinant Protein (N-His-KSI).pdf

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Human SERINC3 Recombinant Protein (N-His-KSI) (HD200012)

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