Human SLC10A1 Recombinant Protein (N-GST & C-His) (HC429032)

Name: Human SLC10A1 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HC429032
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC429032
Description	Recombinant Human SLC10A1 Protein, N-GST & C-His (HC429032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q14973
Protein length	Phe244-Phe284
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Cell growth-inhibiting gene 29 protein, Hepatic sodium/bile acid cotransporter, NTCP, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, SLC10A1, Sodium/taurocholate cotransporting polypeptide, Solute carrier family 10 member 1
Background	Hepatic sodium/bile acid cotransporter is a ~38 kDa protein. As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation. 1. Ho, RH. et al. (2004) The Journal of biological chemistry 279, 7213-22. PMID: 14660639 2. Vaz, FM. et al. (2015) Hepatology (Baltimore, Md.) 61, 260-7. PMID: 24867799 3. Floerl, S. et al. (2021) SLAS discovery : advancing life sciences R & D 26, 1055-1064. PMID: 34060352 4. Hagenbuch, B. et al. (1994) The Journal of clinical investigation 93, 1326-31. PMID: 8132774 5. Kunst, RF. et al. (2021) Hepatology (Baltimore, Md.) 73, 2577-2585. PMID: 33222321
Note	For research use only