Human SLC30A10 Recombinant Protein (N-His) (HB363012)

Name: Human SLC30A10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HB363012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HB363012
Description	Recombinant Human SLC30A10 Protein, N-His (HB363012) expressed in E. coli, spanning Lys300-Gly427. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q6XR72
Protein length	Lys300-Gly427
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	16.35 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Calcium/manganese antiporter SLC30A10; Solute carrier family 30 member 10; Zinc transporter 10; ZnT-10; SLC30A10; ZNT10; ZNT8
Background	Calcium/manganese antiporter SLC30A10 is a ~52 kDa protein. Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes. 1. Levy, M. et al. (2019) The Journal of biological chemistry 294, 5879-5889. PMID: 30755481 2. Tuschl, K. et al. (2012) American journal of human genetics 90, 457-66. PMID: 22341972 3. Leyva-Illades, D. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 14079-95. PMID: 25319704 4. Zhao, Y. et al. (2016) Traffic (Copenhagen, Denmark) 17, 267-88. PMID: 26728129 5. Nishito, Y. et al. (2016) The Journal of biological chemistry 291, 14773-87. PMID: 27226609 6. Zogzas, CE. et al. (2016) The Journal of biological chemistry 291, 15940-57. PMID: 27307044 7. Patrushev, N. et al. (2012) PloS one 7, e33211. PMID: 22427991
Note	For research use only

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SDS-PAGE for Recombinant Human SLC30A10 Protein, N-His

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Datasheet

Human SLC30A10 Recombinant Protein (N-His).pdf

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Human SLC30A10 Recombinant Protein (N-His) (HB363012)

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