Human SLC4A7 Recombinant Protein (N-His) (HA125042)

Name: Human SLC4A7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA125042
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HA125042
Description	Recombinant Human SLC4A7 Protein, N-His (HA125042) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9Y6M7
Protein length	Gly747-His817&Ala 1114-Leu1214
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BT, Bicarbonate transporter, Electroneutral Na/HCO(3) cotransporter, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4A6, SLC4A7, Sodium bicarbonate cotransporter 2, Sodium bicarbonate cotransporter 2b, Sodium bicarbonate cotransporter 3, Solute carrier family 4 member 7
Background	Sodium bicarbonate cotransporter 3 is a ~136 kDa protein. Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. 1. Pushkin, A. et al. (1999) The Journal of biological chemistry 274, 16569-75. PMID: 10347222 2. Park, M. et al. (2002) The Journal of biological chemistry 277, 50503-9. PMID: 12403779 3. Loiselle, FB. et al. (2003) Molecular membrane biology 20, 307-17. PMID: 14578046 4. Loiselle, FB. et al. (2004) American journal of physiology. Cell physiology 286, C1423-33. PMID: 14736710 5. Sedlyarov, V. et al. (2018) Cell host & microbe 23, 766-774.e5. PMID: 29779931 6. Ali, ES. et al. (2022) Molecular cell 82, 3284-3298.e7. PMID: 35772404
Note	For research use only