

| Catalog No. | HD570012 |
|---|---|
| Description |
Recombinant Human SLC6A2 NAT1 NET1 SLC6A5 Protein, N-His-KSI (HD570012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Expression system | E. coli |
| Accession | P23975 |
| Protein length | Phe167-Pro233&Ser363-Thr402&Pro570-Ile617 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Species | Homo sapiens (Human) |
| Nature | Recombinant |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >90% as determined by SDS-PAGE. |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | NAT1, NET, NET1, Norepinephrine transporter, SLC6A2, SLC6A5, Sodium-dependent noradrenaline transporter, Solute carrier family 6 member 2 |
| Background | Sodium-dependent noradrenaline transporter is a ~69 kDa protein. Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine. 1. Pacholczyk, T. et al. (1991) Nature 350, 350-4. PMID: 2008212 2. Gu, H. et al. (1994) The Journal of biological chemistry 269, 7124-30. PMID: 8125921 3. Zhang, H. et al. (2024) Nature 630, 247-254. PMID: 38750358 4. Syringas, M. et al. (2000) Molecular pharmacology 58, 1404-11. PMID: 11093780 5. Brown, CR. et al. (2025) Journal of neurochemistry 169, e16241. PMID: 39395208 6. Tan, J. et al. (2024) Nature 632, 921-929. PMID: 39048818 |
| Note | For research use only |
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