Human SOCS7 Recombinant Protein (N-His) (HC839012)

Name: Human SOCS7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC839012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC839012
Description	Recombinant Human SOCS7 Protein, N-His (HC839012) expressed in E. coli, spanning Ser391-Thr581. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O14512
Protein length	Ser391-Thr581
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	25.02 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	NAP-4, NAP4, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, SOCS-7, SOCS6, SOCS7, Suppressor of cytokine signaling 7
Background	Suppressor of cytokine signaling 7 is a ~62 kDa protein. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. 1. Banks, AS. et al. (2005) The Journal of clinical investigation 115, 2462-71. PMID: 16127460 2. Martens, N. et al. (2005) The Journal of biological chemistry 280, 13817-23. PMID: 15677474
Note	For research use only

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Human SOCS7 Recombinant Protein (N-His).pdf

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Human SOCS7 Recombinant Protein (N-His) (HC839012)

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