Human SRGAP2 Recombinant Protein (N-His) (HF766012)

Name: Human SRGAP2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HF766012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HF766012
Description	Recombinant Human SRGAP2 Protein, N-His (HF766012) expressed in E. coli, spanning Thr494-Phe679. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O75044
Protein length	Thr494-Phe679
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	23.51 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ARHGAP34, FNBP2, Formin-binding protein 2, KIAA0456, Rho GTPase-activating protein 34, SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2, SRGAP2A, srGAP2
Background	SLIT-ROBO Rho GTPase-activating protein 2 is a ~120 kDa protein. Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. 1. Guo, S. et al. (2010) The Journal of biological chemistry 285, 35133-41. PMID: 20810653 2. Fossati, M. et al. (2016) Neuron 91, 356-69. PMID: 27373832 3. Sporny, M. et al. (2017) Molecular biology and evolution 34, 1463-1478. PMID: 28333212 4. Charrier, C. et al. (2012) Cell 149, 923-35. PMID: 22559944 5. Mason, FM. et al. (2011) The Journal of biological chemistry 286, 6577-86. PMID: 21148482
Note	For research use only

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Datasheet

Human SRGAP2 Recombinant Protein (N-His).pdf

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Human SRGAP2 Recombinant Protein (N-His) (HF766012)

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