Human SYVN1 Recombinant Protein (N-GST & C-His) (HC805012)

Name: Human SYVN1 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HC805012
Price: 211 USD
Availability: InStock

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Catalog No.	HC805012
Description	Recombinant Human SYVN1 Protein, N-GST & C-His (HC805012) expressed in E. coli, spanning Arg246-Pro339. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q86TM6
Protein length	Arg246-Pro339
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	39.16 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	E3 ubiquitin-protein ligase synoviolin, EC:2.3.2.27, HRD1, KIAA1810, RING-type E3 ubiquitin transferase synoviolin, SYVN1, Synovial apoptosis inhibitor 1
Background	E3 ubiquitin-protein ligase synoviolin is a ~67 kDa protein. E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. 1. Kaneko, M. et al. (2002) FEBS letters 532, 147-52. PMID: 12459480 2. Nadav, E. et al. (2003) Biochemical and biophysical research communications 303, 91-7. PMID: 12646171 3. Amano, T. et al. (2003) Genes & development 17, 2436-49. PMID: 12975321 4. Kikkert, M. et al. (2004) The Journal of biological chemistry 279, 3525-34. PMID: 14593114 5. Schulze, A. et al. (2005) Journal of molecular biology 354, 1021-7. PMID: 16289116 6. Arteaga, MF. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 11178-83. PMID: 16847254 7. Omura, T. et al. (2006) Journal of neurochemistry 99, 1456-69. PMID: 17059562 8. Yang, H. et al. (2007) Experimental cell research 313, 538-50. PMID: 17141218 9. Yamasaki, S. et al. (2007) The EMBO journal 26, 113-22. PMID: 17170702 10. Sato, T. et al. (2012) Molecular cell 47, 99-110. PMID: 22607976
Note	For research use only

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Human SYVN1 Recombinant Protein (N-GST & C-His).pdf

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Human SYVN1 Recombinant Protein (N-GST & C-His) (HC805012)

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