Human TAB2 Recombinant Protein (N-His-SUMO) (HC762012)

Name: Human TAB2 Recombinant Protein (N-His-SUMO)
Brand: abinScience
SKU: HC762012
Price: 211 USD
Availability: InStock

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Catalog No.	HC762012
Description	Recombinant Human TAB2 Protein, N-His-SUMO (HC762012) expressed in E. coli, spanning Ala2-Ser77. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9NYJ8
Protein length	Ala2-Ser77
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	20.84 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	KIAA0733, MAP3K7IP2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2, TAB2, TAK1-binding protein 2, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, TGF-beta-activated kinase 1-binding protein 2
Background	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 is a ~76 kDa protein. Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. 1. Takaesu, G. et al. (2000) Molecular cell 5, 649-58. PMID: 10882101 2. Wang, C. et al. (2001) Nature 412, 346-51. PMID: 11460167 3. Kanayama, A. et al. (2004) Molecular cell 15, 535-48. PMID: 15327770 4. Zhang, L. et al. (2011) Nature 481, 204-8. PMID: 22158122 5. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020 6. Gu, Z. et al. (2021) Cellular & molecular immunology 18, 1981-1994. PMID: 33184450 7. Zhang, J. et al. (2023) Cell death and differentiation 30, 966-978. PMID: 36681779
Note	For research use only

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Datasheet

Human TAB2 Recombinant Protein (N-His-SUMO).pdf

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Human TAB2 Recombinant Protein (N-His-SUMO) (HC762012)

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