Human TBXAS1 Recombinant Protein (N-His) (HD756012)

Name: Human TBXAS1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD756012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD756012
Description	Recombinant Human TBXAS1 Protein, N-His (HD756012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P24557
Protein length	Gly62-Arg533
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CYP5, CYP5A1, Cytochrome P450 5A1, EC:4.2.1.152, EC:5.3.99.5, Hydroperoxy icosatetraenoate dehydratase, TBXAS1, TXA synthase, TXAS, TXS, Thromboxane-A synthase
Background	Thromboxane-A synthase is a ~60 kDa protein. Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. 1. Hsu, PY. et al. (2000) Archives of biochemistry and biophysics 383, 119-27. PMID: 11097184 2. Wang, LH. et al. (2001) The Journal of biological chemistry 276, 14737-43. PMID: 11297515 3. Chen, CY. et al. (2012) Pharmacogenetics and genomics 22, 653-8. PMID: 22735388 4. Matsunobu, T. et al. (2013) Journal of lipid research 54, 2979-87. PMID: 24009185 5. Yokoyama, C. et al. (1993) FEBS letters 318, 91-4. PMID: 8436233 6. Hsu, PY. et al. (1999) The Journal of biological chemistry 274, 762-9. PMID: 9873013 7. Yeh, HC. et al. (2007) Archives of biochemistry and biophysics 461, 159-68. PMID: 17459323
Note	For research use only

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Datasheet

Human TBXAS1 Recombinant Protein (N-His).pdf

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Human TBXAS1 Recombinant Protein (N-His) (HD756012)

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