Human TGFBR3 Recombinant Protein (N-His) (HA790012)

Name: Human TGFBR3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA790012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HA790012
Description	Recombinant Human TGFBR3 Protein, N-His (HA790012) expressed in E. coli, spanning Ser36-Glu360. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q03167
Protein length	Ser36-Glu360
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.49 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III; TGFBR3
Background	Transforming growth factor beta receptor type 3 is a ~93 kDa protein. Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. 1. Chen, W. et al. (2003) Science (New York, N.Y.) 301, 1394-7. PMID: 12958365 2. Mythreye, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 8221-6. PMID: 19416857 3. Kirkbride, KC. et al. (2008) The Journal of biological chemistry 283, 7628-37. PMID: 18184661 4. Lee, NY. et al. (2009) Molecular biology of the cell 20, 4362-70. PMID: 19726563 5. Mythreye, K. et al. (2013) Oncogene 32, 1416-27. PMID: 22562249 6. You, HJ. et al. (2009) Carcinogenesis 30, 1281-7. PMID: 19325136
Note	For research use only

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SDS-PAGE for Recombinant Human TGFBR3 Protein, N-His

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Datasheet

Human TGFBR3 Recombinant Protein (N-His).pdf

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Human TGFBR3 Recombinant Protein (N-His) (HA790012)

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