Human TXK Recombinant Protein (N-His) (HD030012)

Name: Human TXK Recombinant Protein (N-His)
Brand: abinScience
SKU: HD030012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD030012
Description	Recombinant Human TXK Protein, N-His (HD030012) expressed in E. coli, spanning Ile85-Trp527. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P42681
Protein length	Ile85-Trp527
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	53.87 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.10.2, PTK4, Protein-tyrosine kinase 4, RLK, Resting lymphocyte kinase, TXK, Tyrosine-protein kinase TXK
Background	Tyrosine-protein kinase TXK is a ~61 kDa protein. Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. 1. Takeba, Y. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 2365-70. PMID: 11859127 2. Maruyama, T. et al. (2007) Clinical and experimental immunology 147, 164-75. PMID: 17177976
Note	For research use only

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Datasheet

Human TXK Recombinant Protein (N-His).pdf

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Human TXK Recombinant Protein (N-His) (HD030012)

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