Human USP49 Recombinant Protein (N-His) (HD948012)

Name: Human USP49 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD948012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD948012
Description	Recombinant Human USP49 Protein, N-His (HD948012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q70CQ1
Protein length	Ser356-Ser688
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Deubiquitinating enzyme 49, EC:3.4.19.12, USP49, Ubiquitin carboxyl-terminal hydrolase 49, Ubiquitin thioesterase 49, Ubiquitin-specific-processing protease 49
Background	Ubiquitin carboxyl-terminal hydrolase 49 is a ~79 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity. Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1. Also regulates the mitotic spindle checkpoint and prevents aneuploidy. 1. Zhang, Z. et al. (2013) Genes & development 27, 1581-95. PMID: 23824326 2. Matsui, M. et al. (2022) Gene 833, 146599. PMID: 35598681 3. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942 4. Campos-Iglesias, D. et al. (2023) Cell death & disease 14, 60. PMID: 36702832 5. Ye, L. et al. (2019) PLoS pathogens 15, e1007680. PMID: 30943264 6. Pan, T. et al. (2019) eLife 8. PMID: 31397674
Note	For research use only

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Datasheet

Human USP49 Recombinant Protein (N-His).pdf

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Human USP49 Recombinant Protein (N-His) (HD948012)

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