Human WDR59 Recombinant Protein (N-His) (HC782012)

Name: Human WDR59 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC782012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC782012
Description	Recombinant Human WDR59 Protein, N-His (HC782012) expressed in E. coli, spanning Ala2-Arg315. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q6PJI9
Protein length	Ala2-Arg315
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.62 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GATOR2 complex protein WDR59, KIAA1923, WD repeat-containing protein 59, WDR59
Background	GATOR2 complex protein WDR59 is a ~109 kDa protein. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. 1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238 2. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 3. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210 4. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 5. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027 6. Zhang, Y. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2212330120. PMID: 36577058
Note	For research use only

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Human WDR59 Recombinant Protein (N-His).pdf

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Human WDR59 Recombinant Protein (N-His) (HC782012)

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