Human WHR1 Recombinant Protein (N-His) (HD899012)

Name: Human WHR1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD899012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD899012
Description	Recombinant Human WHR1 Protein, N-His (HD899012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P49842
Protein length	Asp144-Thr254
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	G11, Inactive serine/threonine-protein kinase 19, Protein G11, Protein RP1, RP1, STK19, TWH19, Tandem winged helix protein formerly known as STK19, WHR1, Winged helix repair factor 1
Background	Winged helix repair factor 1 is a ~28 kDa protein. DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. 1. Li, Y. et al. (2024) The Journal of cell biology 223. PMID: 38252411 2. Li, J. et al. (2024) Scientific reports 14, 14098. PMID: 38890355 3. Tan, Y. et al. (2024) Nucleic acids research 52, 12767-12783. PMID: 39353615 4. Ramadhin, AR. et al. (2024) Molecular cell 84, 4740-4757.e12. PMID: 39547223 5. Mevissen, TET. et al. (2024) Cell 187, 7091-7106.e24. PMID: 39547228 6. van den Heuvel, D. et al. (2024) Cell 187, 7107-7125.e25. PMID: 39547229
Note	For research use only

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Datasheet

Human WHR1 Recombinant Protein (N-His).pdf

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Human WHR1 Recombinant Protein (N-His) (HD899012)

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