Human YTHDF1 Recombinant Protein (N-His) (HC802012)

Name: Human YTHDF1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC802012
Price: 211 USD
Availability: InStock

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Catalog No.	HC802012
Description	Recombinant Human YTHDF1 Protein, N-His (HC802012) expressed in E. coli, spanning His365-Gln559. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9BYJ9
Protein length	His365-Gln559
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	25.06 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C20orf21, DACA-1, DF1, Dermatomyositis associated with cancer putative autoantigen 1, YTH domain-containing family protein 1, YTHDF1
Background	YTH domain-containing family protein 1 is a ~60 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs. 1. Wang, X. et al. (2014) Nature 505, 117-20. PMID: 24284625 2. Xu, C. et al. (2015) The Journal of biological chemistry 290, 24902-13. PMID: 26318451 3. Zaccara, S. et al. (2020) Cell 181, 1582-1595.e18. PMID: 32492408 4. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921 5. Shi, H. et al. (2017) Cell research 27, 315-328. PMID: 28106072 6. Ries, RJ. et al. (2019) Nature 571, 424-428. PMID: 31292544
Note	For research use only

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Datasheet

Human YTHDF1 Recombinant Protein (N-His).pdf

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Human YTHDF1 Recombinant Protein (N-His) (HC802012)

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