

| Catalog No. | VK584041 |
|---|---|
| Description |
Recombinant Lyssavirus rabies Glycoprotein G, C-Fc (VK584041) expressed in Mammalian Cells. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Expression system | Mammalian cells |
| Accession | G9G2S5 |
| Protein length | Lys20-Glu458 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Species | Rabies virus (RABV) |
| Nature | Recombinant |
| Endotoxin level | <0.1 EU/ug as determined by LAL method. |
| Purity | >90% as determined by SDS-PAGE. |
| Predicted molecular weight | 77.47 kDa |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | G, Glycoprotein |
| Background | Glycoprotein is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. |
| Note | For research use only |
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