Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc) (MV480011)

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Overview

Catalog No.	MV480011
Description	Recombinant Mouse CD270/TNFRSF14 Protein, C-Fc (MV480011) expressed in Mammalian Cells, spanning Met1-Gln206. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian Cells
Accession	Q80WM9
Protein length	Met1-Gln206
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	48.94 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD270, HVEA, HVEM, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, TNFRSF14, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2
Background	Tumor necrosis factor receptor superfamily member 14 is a ~30 kDa protein. Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network. Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions. Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response. 1. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044 2. Tu, TC. et al. (2015) The Journal of experimental medicine 212, 415-29. PMID: 25711213 3. Shui, JW. et al. (2012) Nature 488, 222-5. PMID: 22801499 4. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026
Note	For research use only

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Datasheet

Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc).pdf

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Mouse CD270/TNFRSF14 Recombinant Protein (C-Fc) (MV480011)

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